2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116549
    Prostaglandin F2α alcohol
    		Agonist
    Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
    Prostaglandin F2α alcohol
  • HY-142972
    19(S)-HETE
    		Agonist
    19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.
    19(S)-HETE
  • HY-W746888
    17-Phenyl trinor prostaglandin F2α diethyl amide
    17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF2α analog with hypotensive efficacy.
    17-Phenyl trinor prostaglandin F2α diethyl amide
  • HY-W714710
    Teopranitol
    		Agonist
    Teopranitol (KC-046), a coronary vasodilator with a rather selective venous dilatation, is used for the study of the acute myocardial ischemia.
    Teopranitol
  • HY-13214
    AM-461
    		Antagonist
    AM-461 is a DP2 receptor (Prostaglandin Receptor) antagonist. AM-461 can be used for the researches of inflammation and immunology, such as asthma.
    AM-461
  • HY-114587
    RS 93427-007
    		Agonist
    RS 93427-007 is an orally active prostacyclin stable mimetic agent. RS 93427-007 can be used for the research of cardiovascular disease, such as atherosclerosis.
    RS 93427-007
  • HY-160664
    TP receptor antagonist-2
    		Antagonist
    TP receptor antagonist-2 (example 7n) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 5.64 and 5.27 μM for TPα and TPβ, respectively. TP receptor antagonist-2 inhibits platelet aggregation.
    TP receptor antagonist-2
  • HY-W009706A
    Alclofenac sodium
    		Inhibitor
    Alclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac sodium is a prostaglandin H2 synthase inhibitor. Alclofenac sodium can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research.
    Alclofenac sodium
  • HY-169630
    DBMB
    		Inhibitor
    DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.
    DBMB
  • HY-157496
    EP3 antagonist 7
    		Antagonist
    EP3 antagonist 7 (Compound II) is an EP3 receptor antagonist. EP3 antagonist 7 can be used in the study of itching, pain, dysuria or stress disorders.
    EP3 antagonist 7
  • HY-130226
    11-epi-PGE1
    11-epi-PGE1 (11β-Prostaglandin E1) is a less potent isomer of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand.
    11-epi-PGE1
  • HY-N10226
    Thielavin B
    		Inhibitor
    Thielavin B is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin B effectively influences the prostaglandin E2 synthesis from the endoperoxide. Thielavin B is significantly effective on carrageenan-induced oedema of rats when administered intravenously.
    Thielavin B
  • HY-B1074R
    Ethamsylate (Standard)
    		Inhibitor
    Ethamsylate (Standard) is the analytical standard of Ethamsylate. This product is intended for research and analytical applications. Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis..
    Ethamsylate (Standard)
  • HY-N4237
    Saikogenin D
    		Inhibitor 99.99%
    Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.
    Saikogenin D
  • HY-118180
    CAY10595
    		Antagonist
    CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
    CAY10595
  • HY-114850
    5-trans Prostaglandin F2β
    5-trans Prostaglandin F2β (5-trans-PGF2β) is the 9β-hydroxy isomer of 5-trans PGF2α.
    5-trans Prostaglandin F2β
  • HY-B0601R
    Tafluprost acid (Standard)
    		Agonist
    Tectoquinone (Standard) is the analytical standard of Tectoquinone. This product is intended for research and analytical applications. Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC50 values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively.
    Tafluprost acid (Standard)
  • HY-19249
    Z-335 sodium
    		Antagonist
    Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively.
    Z-335 sodium
  • HY-157494
    EP3 antagonist 5
    		Antagonist
    EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC50 value of 67 nM.
    EP3 antagonist 5
  • HY-179246
    CXT29
    		Antagonist
    CXT29 is an orally active COX-2 inhibitor and a thromboxane A2 receptor (TP) antagonist. CXT29 exhibits COX inhibitory activity and selectivity, with IC50 values of 13 and 722 nM for COX-2 and COX-1 respectively. CXT29 inhibits platelet aggregation induced by U-46619 (HY-108566) (a TP agonist), with an IC50 of 96 nM. CXT29 effectively inhibits the production of TXB₂ and PGE₂, significantly reducing platelet aggregation and inflammatory pain in mice. CXT29 can be used for research on inflammatory pain and cardiovascular diseases.
    CXT29
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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